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MCC 555
CAS No. 161600-01-7
MCC 555( Isaglitazone | Netoglitazone | RWJ 241947 )
Catalog No. M12353 CAS No. 161600-01-7
MCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 226 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 548 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1190 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMCC 555
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NoteResearch use only, not for human use.
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Brief DescriptionMCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM.
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DescriptionMCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653; profoundly suppresses growth of PC-3 prostate cancer xenografts with prominent apoptosis, as well as fibrosis, including inflammatory and giant cell reaction in the remaining tumor tissue.Diabetes Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsIsaglitazone | Netoglitazone | RWJ 241947
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorPPAR
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number161600-01-7
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Formula Weight381.421
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Molecular FormulaC21H16FNO3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (655.45 mM)
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SMILESO=C(N1)SC(CC2=CC=C3C=C(OCC4=CC=CC=C4F)C=CC3=C2)C1=O
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Chemical Name5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Reginato MJ, et al. J Biol Chem. 1998 Dec 4;273(49):32679-84.
2. Kumagai T, et al. Clin Cancer Res. 2004 Feb 15;10(4):1508-20.
3. Cekanova M, et al. Eur J Pharmacol. 2010 Jul 10;637(1-3):30-7.
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