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BAY 1251152
CAS No. 1610358-56-9
BAY 1251152( +)-BAY 1251152 )
Catalog No. M12323 CAS No. 1610358-56-9
BAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 797 | Get Quote |
|
| 100MG | 1197 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBAY 1251152
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NoteResearch use only, not for human use.
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Brief DescriptionBAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM.
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DescriptionBAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM, displays> 50-fold selectivity against other CDKs;exhibits broad anti-proliferative activity against a panel of tumour cell lines with sub-micromolar IC50 values; demonstrates excellent efficacy in xenograft models (e.g. MOLM13) in mice and rats.Blood Cancer Phase 1 Clinical.
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In Vitro——
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In VivoAnimal Model:Female SCID mice with OCI-LY-3 cells Dosage:10 mg/kg Administration:Intravenous injection; once every seven days; for 14 days Result:Inhibited tumour growth and had good tolerability.
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Synonyms+)-BAY 1251152
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PathwayCell Cycle/DNA Damage
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TargetCDK
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RecptorCDK
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1610358-56-9
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Formula Weight404.436
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Molecular FormulaC19H18F2N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO : 113.3 mg/mL. 280.15 mM
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SMILESN=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O
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Chemical Name(+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ulrich T. Luecking, et al. Abstract 984: Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops. DOI: 10.1158/1538-7445.
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