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DMP 543
CAS No. 160588-45-4
DMP 543( XR-543 | XR 543 | DMP-543 )
Catalog No. M12308 CAS No. 160588-45-4
A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 10MG | 32 | In Stock |
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| 25MG | 65 | In Stock |
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| 50MG | 103 | In Stock |
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| 100MG | 167 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDMP 543
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NoteResearch use only, not for human use.
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Brief DescriptionA potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
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DescriptionA potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM; maintains the 5- to 10-fold potency differential over linopirdine in increasing extracellular hippocampal ACh levels in the rat with a minimum effective dose of 1 mg/kg.Alzheimer Disease Phase 2 Discontinued.
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In VitroDMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM.
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In Vivo——
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SynonymsXR-543 | XR 543 | DMP-543
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number160588-45-4
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Formula Weight412.44
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Molecular FormulaC26H18F2N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (242.47 mM)
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SMILESO=C1C2=C(C=CC=C2)C(CC3=CC(F)=NC=C3)(CC4=CC(F)=NC=C4)C5=CC=CC=C15
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Chemical Name10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Earl RA, et al. J Med Chem. 1998 Nov 5;41(23):4615-22.
2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
3. Pesti JA, et al. J Org Chem. 2000 Nov 17;65(23):7718-22.
4. Ipavec V, et al. Pharmacol Res. 2011 Oct;64(4):397-409.
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