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SKA-111

CAS No. 1369170-24-0

SKA-111( —— )

Catalog No. M34028 CAS No. 1369170-24-0

SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 162 In Stock
5MG 147 In Stock
10MG 250 In Stock
25MG 504 In Stock
50MG 712 In Stock
100MG 995 In Stock
200MG Get Quote In Stock
500MG 2000 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    SKA-111
  • Note
    Research use only, not for human use.
  • Brief Description
    SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.
  • Description
    SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Langendorff in rat hearts Dosage:1 μM Administration:Cardiac perfusion Result:Potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1369170-24-0
  • Formula Weight
    214.29
  • Molecular Formula
    C12H10N2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (466.66 mM; Ultrasonic )
  • SMILES
    NC1=NC=2C=3C(C(C)=CC2S1)=CC=CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. ?
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