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BTS
CAS No. 1576-37-0
BTS( N-Benzyl-p-toluenesulfonamide | N-Tosylbenzylamine )
Catalog No. M12252 CAS No. 1576-37-0
A highly specific myosin II ATPase inhibitor; inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1G | 26 | In Stock |
|
Biological Information
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Product NameBTS
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NoteResearch use only, not for human use.
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Brief DescriptionA highly specific myosin II ATPase inhibitor; inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility.
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DescriptionA highly specific myosin II ATPase inhibitor; inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility; inhibits isometric Ca2+-activated tension with IC50 of 3 uM in glycerol-extracted fibres from rabbit psoas muscle; specific and no activity for platelet myosin II.
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In VitroBTS (2-12 μM) inhibits the Ca2+-stimulated ATPase activity of myosin S1 in the absence of actin, with an IC50 of ~5 μM.BTS (2-20 μM) reversibly inhibits the gliding motility rate of heavy meromyosin (HMM).BTS (100 μM) releases myosin from actin in the presence of ADP.BTS (0-20 μM) reversibly inhibits isometric Ca2+-activated tension in skinned skeletal muscle fibres from rabbit and frog, with IC50s of ~3 μM and 1 μM, respectively.
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In Vivo——
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SynonymsN-Benzyl-p-toluenesulfonamide | N-Tosylbenzylamine
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMyosin
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RecptorMyosin
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1576-37-0
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Formula Weight261.3394
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Molecular FormulaC14H15NO2S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=S(C1=CC=C(C)C=C1)(NCC2=CC=CC=C2)=O
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Chemical NameBenzenesulfonamide, 4-methyl-N-(phenylmethyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cheung A, et al. Nat Cell Biol. 2002 Jan;4(1):83-8.
2. Blair DR, et al. Am J Physiol Endocrinol Metab. 2009 May;296(5):E993-E1002.
3. Abi-Gerges N, et al. J Mol Cell Cardiol. 2013 Nov;64:108-19.
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