ICSN3250 hydrochloride( ICSN-3250 )

Catalog No. M12224 CAS No. 1561902-79-1

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Product Name

ICSN3250 hydrochloride
Note

Research use only, not for human use.
Brief Description

ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor.
Description

ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors; ICSN3250 is not a kinase inhibitor of mTOR, competes with and displaces phosphatidic acid from the FRB domain in mTOR, thus preventing mTOR activation and leading to cytotoxicity; displays no inhibitory capacity towards PI3Kα, β, γ, or δ; inhibits mTORC1 by following an unprecedented mechanism that involved its competition with PA at the FRB domain of mTOR to overcome the TSC negative regulation of mTORC1; ICSN3250 specifically targets cancer cells both in vitro and ex vivo.
In Vitro

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In Vivo

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Synonyms

ICSN-3250
Pathway

PI3K/Akt/mTOR signaling
Target

mTOR
Recptor

mTOR
Research Area

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Indication

——

CAS Number

1561902-79-1
Formula Weight

633.139
Molecular Formula

C31H41ClN4O8
Purity

>98% (HPLC)
Solubility

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SMILES

C1CCCCCCN(CCCCC1)CCCN2C=C(C(=C2)C3=CC(=C(C(=C3)O)O)[N+](=O)[O-])C4=CC(=C(C(=C4)O)O)[N+](=O)[O-].Cl
Chemical Name

5,5'-(1-(3-(azacyclotridecan-1-yl)propyl)-1H-pyrrole-3,4-diyl)bis(3-nitrobenzene-1,2-diol) hydrochloride

1. Nguyen TL, et al. Cancer Res. 2018 Jul 27. pii: canres.0232.2018.

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