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PFM01
CAS No. 1558598-41-6
PFM01( SML1735 )
Catalog No. M12217 CAS No. 1558598-41-6
PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 36 | In Stock |
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| 25MG | 70 | In Stock |
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| 50MG | 127 | In Stock |
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| 100MG | 207 | In Stock |
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| 200MG | 288 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePFM01
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NoteResearch use only, not for human use.
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Brief DescriptionPFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity.
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DescriptionPFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity.
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In VitroPFM01 (100 μM) rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells.PFM01 (100 μM) diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells.PFM01 (100 μM) enhances non-homologous end-joining(NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells.PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells.
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In Vivo——
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SynonymsSML1735
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorDNA Repair Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number1558598-41-6
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Formula Weight293.399
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Molecular FormulaC14H15NO2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (340.83 mM)
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SMILESO=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S
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Chemical Name(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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