PFM01( SML1735 )

Catalog No. M12217 CAS No. 1558598-41-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PFM01
Note

Research use only, not for human use.
Brief Description

PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity.
Description

PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity.
In Vitro

PFM01 (100 μM) rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells.PFM01 (100 μM) diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells.PFM01 (100 μM) enhances non-homologous end-joining(NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells.PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells.
In Vivo

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Synonyms

SML1735
Pathway

Cell Cycle/DNA Damage
Target

DNA Repair Protein
Recptor

DNA Repair Protein
Research Area

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Indication

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CAS Number

1558598-41-6
Formula Weight

293.399
Molecular Formula

C14H15NO2S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 100 mg/mL (340.83 mM)
SMILES

O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S
Chemical Name

(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone

1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18. 2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

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