Cart
sales@molnova.com
AD-35 hydrochloride
CAS No. 1531586-62-5
AD-35 hydrochloride( AD35 hydrochloride | AD 35 hydrochloride )
Catalog No. M12149 CAS No. 1531586-62-5
A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAD-35 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionA donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
-
DescriptionA donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.
-
In Vitro——
-
In Vivo——
-
SynonymsAD35 hydrochloride | AD 35 hydrochloride
-
PathwayMetabolic Enzyme/Protease
-
TargetAChE
-
RecptorAChE
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1531586-62-5
-
Formula Weight441.956
-
Molecular FormulaC24H28ClN3O3
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILES——
-
Chemical Name6'-(2-(1-(pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.
molnova catalog
related products
-
Malathion
Malathion is an organophosphate parasympathomimetic which binds irreversibly to cholinesterase, is an insecticide of relatively low human toxicity.
-
AChE/BChE-IN-10
AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation.
-
PE 154
PE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively.
