AD-35( AD 35 | AD35 )

Catalog No. M12148 CAS No. 1531586-58-9

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HNMR

HPLC

MSDS

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Product Name

AD-35
Note

Research use only, not for human use.
Brief Description

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
Description

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.
In Vitro

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In Vivo

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Synonyms

AD 35 | AD35
Pathway

Metabolic Enzyme/Protease
Target

AChE
Recptor

AChE
Research Area

——
Indication

——

CAS Number

1531586-58-9
Formula Weight

405.498
Molecular Formula

C24H27N3O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C1N(CCC2CCN(CC3=NC=CC=C3)CC2)C4(C5=C1C=C(OCO6)C6=C5)CC4
Chemical Name

6'-(2-(1-(pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one

1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.

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