BMY 45778

Research use only, not for human use.

A potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.

A potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation; activates adenylyl cyclase (ED50=6-10 nM) and stimulates GTPase in human platelet membrane preparations; prevents [3H]]Iloprost binding to platelet membranes with IC50 of 7 nM, causes elevation of platelet cAMP levels (cAMP content doubles at 13 nM) and activation of the cAMP-dependent protein kinase in whole platelets. Dyslipidemia Discontinued.

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BMY-45778 | BMY45778

GPCR/G Protein

Prostaglandin Receptor

Prostaglandin Receptor

Cardiovascular Disease

Dyslipidemia

152575-66-1

438.44

C26H18N2O5

>98% (HPLC)

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O=C(O)COC1=CC=CC(C2=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)N=CO2)=C1

[3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid

(-20℃)

With Ice Pack

≥ 2 years