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Ro 46-2005
CAS No. 150725-87-4
Ro 46-2005( Ro-462005 )
Catalog No. M12102 CAS No. 150725-87-4
Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 40 | In Stock |
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| 5MG | 36 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 126 | In Stock |
|
| 50MG | 207 | In Stock |
|
| 100MG | 297 | In Stock |
|
| 200MG | 429 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRo 46-2005
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NoteResearch use only, not for human use.
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Brief DescriptionRo 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.
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DescriptionRo 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB; has no effect on plasma concentrations of big ET-1 and only a minor effect on those of ET-3; sufficient to inhibit the pressor effect of the precursor big ET-1 at much lower doses (1 to 10 mg/kg i.v.).Hypertension Preclinical.
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In Vitro——
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In Vivo——
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SynonymsRo-462005
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PathwayGPCR/G Protein
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TargetEndothelin Receptor
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RecptorET-A|ET-B
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Research AreaCardiovascular Disease
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IndicationHypertension
Chemical Information
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CAS Number150725-87-4
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Formula Weight473.542
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Molecular FormulaC23H27N3O6S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 28 mg/mL
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SMILESO=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC=NC(OCCO)=C2OC3=CC=CC(OC)=C3)=O
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Chemical NameBenzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Clozel M, et al. Nature. 1993 Oct 21;365(6448):759-61.
2. Breu V, et al. FEBS Lett. 1993 Nov 15;334(2):210-4.
3. Clozel M, et al. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S377-9.
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