Ro 46-2005

CAS No. 150725-87-4

Ro 46-2005( Ro-462005 )

Catalog No. M12102 CAS No. 150725-87-4

Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 40 In Stock
5MG 36 In Stock
10MG 69 In Stock
25MG 126 In Stock
50MG 207 In Stock
100MG 297 In Stock
200MG 429 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Ro 46-2005
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.
  • Description
    Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB; has no effect on plasma concentrations of big ET-1 and only a minor effect on those of ET-3; sufficient to inhibit the pressor effect of the precursor big ET-1 at much lower doses (1 to 10 mg/kg i.v.).Hypertension Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Ro-462005
  • Pathway
    GPCR/G Protein
  • Target
    Endothelin Receptor
  • Recptor
    ET-A|ET-B
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypertension

Chemical Information

  • CAS Number
    150725-87-4
  • Formula Weight
    473.542
  • Molecular Formula
    C23H27N3O6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC=NC(OCCO)=C2OC3=CC=CC(OC)=C3)=O
  • Chemical Name
    Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Clozel M, et al. Nature. 1993 Oct 21;365(6448):759-61. 2. Breu V, et al. FEBS Lett. 1993 Nov 15;334(2):210-4. 3. Clozel M, et al. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S377-9.
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