Calcium folinate

Research use only, not for human use.

Leucovorin Calcium is a reduced folic acid.

Leucovorin Calcium is a reduced folic acid.(In Vitro):MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .(In Vivo):Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).

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Animal Model:24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g) Dosage:7.0 mg/kg Administration:Intraperitoneal injection; every second day; for 3 weeks Result:Following methotrexate (MTX) administration appears to reverse this growth inhibition.

DL-Folinate | NSC 3590

Cell Cycle/DNA Damage

DNA/RNA Synthesis

Thymidylate synthase| VB

Cancer

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1492-18-8

511.51

C20H21CaN7O7

>98% (HPLC)

Soluble in Water

O=P(O)(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C23)[C@H](O)[C@@H]1O)O

[(2R,3S,4R,5R)-5-[6-(Benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

(-20℃)

With Ice Pack

≥ 2 years