NMS-P645( NMS P645 )

Catalog No. M12046 CAS No. 1482518-95-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NMS-P645
Note

Research use only, not for human use.
Brief Description

NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.
Description

NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively; exhibits excellent selectivity against a large panel of kinases; reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments; induces a significant anti-proliferative response in PCa cells combined with GDC-0941.
In Vitro

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In Vivo

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Synonyms

NMS P645
Pathway

JAK/STAT Signaling
Target

Pim
Recptor

Pim
Research Area

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Indication

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CAS Number

1482518-95-5
Formula Weight

512.095
Molecular Formula

C28H38ClN5O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

2-((S)-7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)-N-((S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethyl)acetamide

1. Casuscelli F, et al. Bioorg Med Chem. 2013 Dec 1;21(23):7364-80. 2. Mologni L, et al. J Cancer. 2017 Jan 1;8(1):140-145.

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