Taprenepag( CP-544326 | CP544326,Taprenepag, PF-0421732 metabolite )

Catalog No. M17589 CAS No. 752187-80-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Taprenepag
Note

Research use only, not for human use.
Brief Description

Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM).
Description

Taprenepag, also known as CP-544326, is a potent and selective EP(2) receptor agonist, was successfully evaluated for its ocular hypotensive activity in a clinical study involving patients with primary open angle glaucoma. Taprenepag is the active metabolite of PF-04217329.(In Vitro):Taprenepag (CP-544326) (0.01-1000 nM) increases cAMP levels in HEK293 cells expressing human EP2 (EC50=2.8 nM). Taprenepag has poor corneal permeability in an ex vivo rabbit corneal model.
In Vitro

Taprenepag (CP-544326) (0.01-1000 nM) increases cAMP levels in HEK293 cells expressing human EP2 (EC50=2.8 nM). Taprenepag has poor corneal permeability in an ex vivo rabbit corneal model.
In Vivo

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Synonyms

CP-544326 | CP544326,Taprenepag, PF-0421732 metabolite
Pathway

JAK/STAT Signaling
Target

Pim
Recptor

PGE2
Research Area

Others-Field
Indication

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CAS Number

752187-80-7
Formula Weight

478.52
Molecular Formula

C24H22N4O5S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 31 mg/mL; 64.78 mM
SMILES

c1cc(cc(c1)OCC(=O)O)CN(Cc1ccc(cc1)n1cccn1)S(=O)(=O)c1cnccc1
Chemical Name

2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid

1. Prasanna G, et al. Exp Eye Res. 2011 Sep;93(3):256-64.

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