VH-032( VHL ligand 1 )

Catalog No. M11909 CAS No. 1448188-62-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

VH-032
Note

Research use only, not for human use.
Brief Description

VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.
Description

VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

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Synonyms

VHL ligand 1
Pathway

PROTACs
Target

E3 Ligase Ligand
Recptor

E3 Ligase Ligand
Research Area

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Indication

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CAS Number

1448188-62-2
Formula Weight

472.604
Molecular Formula

C24H32N4O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (211.60 mM)
SMILES

CC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O
Chemical Name

(2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

1. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. 2. Galdeano C, et al. J Med Chem. 2014 Oct 23;57(20):8657-63.

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