TCH-165( TCH165 )

Catalog No. M11896 CAS No. 1446350-60-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

TCH-165
Note

Research use only, not for human use.
Brief Description

TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes.
Description

TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation; enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture; display a decrease in assembled 26S and an increase in 20S proteasome in treated cells.
In Vitro

Cell Viability Assay Cell Line:RPMI8226 and U87MG cellsConcentration:0.01-10 μM Incubation Time:72 hours Result:Inhibited cell growth of RPMI8226 and U87MG cells with IC50 of 1.6 μM and 2.4 μM, respectively.Western Blot Analysis Cell Line:HEK293T cells Concentration:0 μM, 3 μM, 10 μMIncubation Time:24 hours Result:Enhanced proteolytic degradation in a concentration-dependent manner.
In Vivo

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Synonyms

TCH165
Pathway

Proteasome/Ubiquitin
Target

Proteasome
Recptor

Proteasome
Research Area

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Indication

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CAS Number

1446350-60-2
Formula Weight

595.743
Molecular Formula

C39H37N3O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (419.65 mM)
SMILES

O=C([C@@]1(C2=CC=CC=C2)N=C(C3=CC=C(OC)C=C3)N(CC4=CC=CC=C4)[C@H]1C5=CC=C(NCC6=CC=CC=C6)C=C5)OCC
Chemical Name

ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

1. Njomen E, et al. Biochemistry. 2018 Jul 17;57(28):4214-4224. 2. Azevedo LM, et al. J Med Chem. 2013 Jul 25;56(14):5974-8.

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