HBX-19818( HBX19818 | HBX-19818 | HBX 19818 )

Catalog No. M11802 CAS No. 1426944-49-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

HBX-19818
Note

Research use only, not for human use.
Brief Description

HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.
Description

HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM; exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrests HCT116 cancer cells in G1.
In Vitro

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In Vivo

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Synonyms

HBX19818 | HBX-19818 | HBX 19818
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

Cancer
Indication

——

CAS Number

1426944-49-1
Formula Weight

421.96
Molecular Formula

C25H28ClN3O
Purity

>98% (HPLC)
Solubility

DMSO: 3.5 mg/mL; DMSO: 5.3 mg/mL (Need ultrasonic)
SMILES

O=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(C)CC4=CC=CC=C4
Chemical Name

2-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-

1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.

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