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Seclidemstat
CAS No. 1423715-37-0
Seclidemstat( SP-2577 | SP2577 )
Catalog No. M11789 CAS No. 1423715-37-0
Seclidemstat (SP-2577, SP2577) is a potent, selective LSD1 inhibitor with IC50 of 127 nM, reduces tumor volume in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
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| 5MG | 39 | In Stock |
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| 10MG | 63 | In Stock |
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| 25MG | 117 | In Stock |
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| 50MG | 183 | In Stock |
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| 100MG | 347 | In Stock |
|
| 200MG | 517 | In Stock |
|
| 500MG | 833 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSeclidemstat
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NoteResearch use only, not for human use.
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Brief DescriptionSeclidemstat (SP-2577, SP2577) is a potent, selective LSD1 inhibitor with IC50 of 127 nM, reduces tumor volume in vivo.
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DescriptionSeclidemstat (SP-2577, SP2577) is a potent, selective LSD1 inhibitor with IC50 of 127 nM, reduces tumor volume in vivo.(In Vitro):Seclidemstat (72 hours) inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC50 ranging from 0.013 to 2.819 μM (COV434, BIN67, SCCOHT-1, TOV21G, SKOV3, A427, H522, A549, H1299, G401, G402, HCC15 cells).Seclidemstat (72 hours) promotes endogenous retroviruses (ERVs) expression and activation of IFNβ pathway in SCCOHT cell lines (SCCOHT-1, BIN67, and COV434 cells).Seclidemstat (3 μM) promotes PD-L1 expression in SCCOHT COV 434 pIND 20 BRG1-2.7 cell line.
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In Vitro——
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In Vivo——
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SynonymsSP-2577 | SP2577
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorLSD1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1423715-37-0
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Formula Weight450.938
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Molecular FormulaC20H23ClN4O4S
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Purity>98% (HPLC)
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SolubilityDMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCN(C)CC3)=O)=C2
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Chemical NameN'-[(1E)-1-(5-chloro-2-hydroxyphenyl)ethylidene]-3-(4-methylpiperazine-1-sulfonyl)benzohydrazide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Patent?WO/2017/004519 A1.
molnova catalog
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