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KPT-330
CAS No. 1421923-86-5
KPT-330( (E)-RN )
Catalog No. M11769 CAS No. 1421923-86-5
KPT-330 inhibited proliferation and induced cell cycle arrest and apoptosis-related proteins in 11 NSCLC cells lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 84 | In Stock |
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| 25MG | 178 | In Stock |
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| 50MG | 321 | In Stock |
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| 100MG | 476 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKPT-330
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NoteResearch use only, not for human use.
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Brief DescriptionKPT-330 inhibited proliferation and induced cell cycle arrest and apoptosis-related proteins in 11 NSCLC cells lines.
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DescriptionKPT-330 inhibited proliferation and induced cell cycle arrest and apoptosis-related proteins in 11 NSCLC cells lines. Moreover, the combination of KPT-330 with cisplatin synergistically enhanced the cell kill of the NSCLC cells in vitro. Human NSCLC tumours growing in immunodeficient mice were markedly inhibited by KPT-330. Also, KPT-330 was effective even against NSCLC cells with a transforming mutation of either exon 20 of EGFR, TP53, phosphatase and tensin homologue, RAS or PIK3CA, suggesting the drug might be effective against a variety of lung Ys irrespective of their driver mutation.
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In Vitro——
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In Vivo——
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Synonyms(E)-RN
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PathwayMembrane Transporter/Ion Channel
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TargetCRM1
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RecptorCRM1| XPO1
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Research Area——
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Indication——
Chemical Information
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CAS Number1421923-86-5
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Formula Weight443.31
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Molecular FormulaC17H11F6N7O
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Purity>98% (HPLC)
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SolubilitySoluble in DMSO
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SMILESC1=CN=C(C=N1)NNC(=O)/C=C/N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Christopher J. Walker,et al. Blood. 2013 Oct 24; 122(17): 3034–3044.
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