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NSC 625987
CAS No. 141992-47-4
NSC 625987( NSC 625987 | NSC-625987 | NSC625987 | Cdk4 Inhibitor II )
Catalog No. M11755 CAS No. 141992-47-4
NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 688 | Get Quote |
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| 100MG | 1071 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNSC 625987
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NoteResearch use only, not for human use.
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Brief DescriptionNSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
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DescriptionNSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
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In VitroNSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%.
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In Vivo——
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SynonymsNSC 625987 | NSC-625987 | NSC625987 | Cdk4 Inhibitor II
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number141992-47-4
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Formula Weight271.33
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Molecular FormulaC15H13NO2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (368.55 mM)
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SMILESS=C1C2=C(C=CC=C2)NC3=C(OC)C=CC(OC)=C13
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Chemical Name1,4-Dimethoxy-9(10H)-acridinethione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kubo A, et al. Clin Cancer Res. 1999 Dec;5(12):4279-86.
2. McInnes C, et al. Chem Biol. 2004 Apr;11(4):525-34.
3. Lang E, et al. Cell Physiol Biochem. 2015;37(3):1178-86.
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