HDAC8-IN-22d( HDAC8-IN-1 | MDK-7933 | MDK 7933 | MDK7933 )

Catalog No. M11745 CAS No. 1417997-93-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

HDAC8-IN-22d
Note

Research use only, not for human use.
Brief Description

HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM.
Description

HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3; shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); exhibits cytotoxicity against human lung CL1-5 cells (IC50=7.0 uM) similar to that of SAHA yet without significant cytotoxicity for normal IMR-90 cells.
In Vitro

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells.
In Vivo

——
Synonyms

HDAC8-IN-1 | MDK-7933 | MDK 7933 | MDK7933
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC8
Research Area

——
Indication

——

CAS Number

1417997-93-3
Formula Weight

345.398
Molecular Formula

C22H19NO3
Purity

>98% (HPLC)
Solubility

DMSO: 130 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O
Chemical Name

(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide

1. Huang WJ, et al. ChemMedChem. 2012 Oct;7(10):1815-24.

Calculator

molnova catalog