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HDAC8-IN-22d
CAS No. 1417997-93-3
HDAC8-IN-22d( HDAC8-IN-1 | MDK-7933 | MDK 7933 | MDK7933 )
Catalog No. M11745 CAS No. 1417997-93-3
HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 64 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 87 | In Stock |
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| 25MG | 176 | In Stock |
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| 50MG | 267 | In Stock |
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| 100MG | 341 | In Stock |
|
| 200MG | 483 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHDAC8-IN-22d
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NoteResearch use only, not for human use.
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Brief DescriptionHDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM.
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DescriptionHDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3; shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); exhibits cytotoxicity against human lung CL1-5 cells (IC50=7.0 uM) similar to that of SAHA yet without significant cytotoxicity for normal IMR-90 cells.
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In VitroHDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells.
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In Vivo——
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SynonymsHDAC8-IN-1 | MDK-7933 | MDK 7933 | MDK7933
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC8
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Research Area——
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Indication——
Chemical Information
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CAS Number1417997-93-3
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Formula Weight345.398
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Molecular FormulaC22H19NO3
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Purity>98% (HPLC)
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SolubilityDMSO: 130 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O
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Chemical Name(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang WJ, et al. ChemMedChem. 2012 Oct;7(10):1815-24.
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