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Proxalutamide
CAS No. 1398046-21-3
Proxalutamide( GT-0918 | GT 0918 )
Catalog No. M11663 CAS No. 1398046-21-3
A potent androgen receptor (AR) antagonist with ability to down regulate AR protein level in prostate cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 187 | In Stock |
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| 5MG | 164 | In Stock |
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| 10MG | 252 | In Stock |
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| 25MG | 503 | In Stock |
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| 50MG | 753 | In Stock |
|
| 100MG | 1097 | In Stock |
|
| 200MG | 1469 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameProxalutamide
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NoteResearch use only, not for human use.
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Brief DescriptionA potent androgen receptor (AR) antagonist with ability to down regulate AR protein level in prostate cancer cells.
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DescriptionA potent androgen receptor (AR) antagonist with ability to down regulate AR protein level in prostate cancer cells; more potently inhibits androgen binding with AR's ligand binding domain than Bicalutamide (11.4-fold) and MDV3100 (3.5-fold) in biochemical assay; demonstrates stronger potency to block AR function of gene transcription in CRPC cells; demonstrates good anti-tumor efficacy among hormone sensitive, CRPC and AR+ breast cancer animal models.Prostate Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsGT-0918 | GT 0918
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PathwayEndocrinology/Hormones
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TargetAndrogen Receptor (AR)
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RecptorAndrogen Receptor (AR)
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Research AreaCancer
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IndicationProstate Cancer
Chemical Information
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CAS Number1398046-21-3
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Formula Weight517.5
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Molecular FormulaC24H19F4N5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESN#CC1=CC=C(N(C(N(C2=CC=C(CCCC3=NC=CO3)N=C2)C4(C)C)=S)C4=O)C(F)=C1C(F)(F)F
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Chemical Name4-[4,4-Dimethyl-3-[6-[3-(2-oxazolyl)propyl]-3-pyridinyl]-5-oxo-2-thioxo-1-imidazolidinyl]-3-fluoro-2-(trifluoromethyl)benzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Youzhi Tong, et al. DOI: 10.1158/1538-7445.AM2014-614 Published October 2014
2. Yang M, et al. Int J Pharm. 2014 Nov 20;475(1-2):97-109.
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