Diacerein

Research use only, not for human use.

Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.

Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.

Cell Viability Assay Cell Line:Cal-78 and SW-1353 cells.Concentration:30, 100, and 300 μM Incubation Time:24, 48 h Result:Inhibited cell growth in a concentration dependent manner in both cell lines.Cell Cycle Analysis Cell Line:Cal-78 and SW-1353 cells.Concentration:30, 100, and 300 μM Incubation Time:48 h Result:Caused a pronounced decrease in the number of cells in the G1 phase, accompanied by a significant increase of the number of S and G2/M phase cells, indicating a G2/M arrest in SW-1353 cells.Western Blot Analysis Cell Line:Cal-78 and SW-1353 cells Concentration:30, 100, and 300 μM Incubation Time:24 h Result:Induced a small, but not significant change, for the expression of CDK1, whereas the cyclin B1 and CDK2 levels were significantly down-regulated in the case of Cal-78 cells.

Animal Model:Male BALB/c mice at 6-8 weeks of age Dosage:50, 100, 200 mg/kg Administration:Gavaged; daily; a week Result:Reduced systematic inflammation and mucus secretion in vivo. Exhibited anti-inflammatory property to significantly reduce inflammation and repair damaged airway.

DAR | 4,5-Diacetylrhein | SF 277

Apoptosis

IL Receptor

IL-1β

Inflammation/Immunology

——

13739-02-1

368.29

C19H12O8

>98% (HPLC)

DMSO: 48 mg/mL (130.33 mM)

O=C(C(C=C1C2=O)=CC(OC(C)=O)=C1C(C3=C2C=CC=C3OC(C)=O)=O)O

4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid

(-20℃)

With Ice Pack

≥ 2 years