Diacerein

CAS No. 13739-02-1

Diacerein( DAR | 4,5-Diacetylrhein | SF 277 )

Catalog No. M11541 CAS No. 13739-02-1

Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
50MG 47 In Stock
100MG 65 In Stock
200MG Get Quote In Stock
500MG 152 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Diacerein
  • Note
    Research use only, not for human use.
  • Brief Description
    Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.
  • Description
    Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.
  • In Vitro
    Cell Viability Assay Cell Line:Cal-78 and SW-1353 cells.Concentration:30, 100, and 300 μM Incubation Time:24, 48 h Result:Inhibited cell growth in a concentration dependent manner in both cell lines.Cell Cycle Analysis Cell Line:Cal-78 and SW-1353 cells.Concentration:30, 100, and 300 μM Incubation Time:48 h Result:Caused a pronounced decrease in the number of cells in the G1 phase, accompanied by a significant increase of the number of S and G2/M phase cells, indicating a G2/M arrest in SW-1353 cells.Western Blot Analysis Cell Line:Cal-78 and SW-1353 cells Concentration:30, 100, and 300 μM Incubation Time:24 h Result:Induced a small, but not significant change, for the expression of CDK1, whereas the cyclin B1 and CDK2 levels were significantly down-regulated in the case of Cal-78 cells.
  • In Vivo
    Animal Model:Male BALB/c mice at 6-8 weeks of age Dosage:50, 100, 200 mg/kg Administration:Gavaged; daily; a week Result:Reduced systematic inflammation and mucus secretion in vivo. Exhibited anti-inflammatory property to significantly reduce inflammation and repair damaged airway.
  • Synonyms
    DAR | 4,5-Diacetylrhein | SF 277
  • Pathway
    Apoptosis
  • Target
    IL Receptor
  • Recptor
    IL-1β
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    13739-02-1
  • Formula Weight
    368.29
  • Molecular Formula
    C19H12O8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 48 mg/mL (130.33 mM)
  • SMILES
    O=C(C(C=C1C2=O)=CC(OC(C)=O)=C1C(C3=C2C=CC=C3OC(C)=O)=O)O
  • Chemical Name
    4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yaron M, et al. Osteoarthritis Cartilage, 1999, 7(3), 272-280.
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