Chrysosplenol D

Research use only, not for human use.

Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.

Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.(In Vitro):Trace amounts of the antimalarial sesquiterpene lactone artemisinin may account for the activity of the n-hexane fraction but only the methoxylated flavonoids artemetin, chrysoplenetin, Chrysosplenol D and cirsilineol can account for the activity of the chloroform extract. These purified flavonoids were found to have IC50 values at 2.4 - 6.5 x 10(-5)M against P. falciparum in vitro compared with an IC50 value of about 3 x 10(-8)M for purified artimisinin. Chrysosplenol D inhibited the viability of the MDA-MB-231 TNBC cells after 48 h with IC50 values of 11.6 μM. The most sensitive cell line towards Chrysosplenol D was the non-small-cell lung carcinoma (NSCLC) cell line A549 and the most resistant one was the androgen-independent prostate carcinoma cell line PC-3. The hormone-sensitive breast cancer cells MCF7 exhibited high resistance towards Chrysosplenol D treatment.(In Vivo):In mice, administration of Chrysosplenol D (1 and 1.5μmol/cm^2) inhibited croton oil-induced ear edema (37.76-65.89%, all P<0.05) in a manner similar to indomethacin (0.5, 1 and 1.5μmol/cm^2; 55.63-84.58%). Chrysosplenol D (0.07, 0.14 and 0.28mmol/kg) protected against LPS-induced systemic inflammatory response syndrome (SIRS) in mice (all P<0.05), in a manner similar to dexamethasone (0.03mmol/kg). Chrysosplenol D suppressed LPS-induced release of IL-1 beta, IL-6 and MCP-1, inhibited cell migration, and reduced LPS-induced IκB and c-JUN phosphorylation in Raw264.7 cells.

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Apoptosis

IL Receptor

IL Receptor

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14965-20-9

360.318

C18H16O8

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (138.77 mM)

COc1cc2oc(-c3ccc(O)c(O)c3)c(OC)c(=O)c2c(O)c1OC

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(-20℃)

With Ice Pack

≥ 2 years