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M4284

CAS No. 1373346-85-0

M4284( M-4284 | M 4284 )

Catalog No. M11539 CAS No. 1373346-85-0

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 272 In Stock
5MG 269 In Stock
10MG 432 In Stock
25MG 715 In Stock
50MG 986 In Stock
100MG 1330 In Stock
200MG Get Quote In Stock
500MG 2660 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    M4284
  • Note
    Research use only, not for human use.
  • Brief Description
    M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
  • Description
    M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay; reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota; reduces UTI89 levels in the gut and urinary tracts of mice.
  • In Vitro
    ——
  • In Vivo
    M4284 (oral administration; 100 mg/kg; 3 doses) can reduces UTI89 levels in the gut and urinary tracts of mice that are concurrently colonized with UTI89 in the gut and bladder. And treating mice with additonal M4284 doses further reduces the UTI89 population and the number of UPEC is lower in M4284-treated mice after termination of treatment. Animal Model:C3H/HeN mice.Dosage:100 mg/kg Administration:Oral administation; a single dose.Result:Had activities against different UPEC strains in different host genetic backgrounds and gut microbial community contexts.
  • Synonyms
    M-4284 | M 4284
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    1373346-85-0
  • Formula Weight
    460.483
  • Molecular Formula
    C23H28N2O8
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (271.46 mM)
  • SMILES
    CC1=C(C=CC(=C1)C2=CC(=CC(=C2)C(=O)NC)C(=O)NC)OC3C(C(C(C(O3)CO)O)O)O
  • Chemical Name
    N3,N5,3'-trimethyl-4'-(((3S,4R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-3,5-dicarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Spaulding CN, et al. Nature. 2017 Jun 22;546(7659):528-532. 2. Jarvis C, et al. ChemMedChem. 2016 Feb 17;11(4):367-73. 3. Han Z, et al. J Med Chem. 2012 Apr 26;55(8):3945-59.
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