Rolofylline

CAS No. 136199-02-5

Rolofylline( KW-3902 | KW3902 )

Catalog No. M11492 CAS No. 136199-02-5

A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 103 In Stock
5MG 79 In Stock
10MG 112 In Stock
25MG 188 In Stock
50MG 272 In Stock
100MG 403 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Rolofylline
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
  • Description
    A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM; displays 290-fold selectivity over A2AR; antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).Heart Failure Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KW-3902 | KW3902
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136199-02-5
  • Formula Weight
    356.46
  • Molecular Formula
    C20H28N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (56.11 mM)
  • SMILES
    O=C(N1CCC)N(CCC)C2=C(NC([C@@]3([C@@H]4C5)C[C@H](C4)C[C@H]5C3)=N2)C1=O
  • Chemical Name
    8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mizumoto H, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):200-6. 2. Shimada J, et al. J Med Chem. 1992 Mar 6;35(5):924-30.
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