Rolofylline( KW-3902 | KW3902 )

Catalog No. M11492 CAS No. 136199-02-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Rolofylline
Note

Research use only, not for human use.
Brief Description

A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
Description

A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM; displays 290-fold selectivity over A2AR; antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).Heart Failure Phase 3 Discontinued.
In Vitro

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In Vivo

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Synonyms

KW-3902 | KW3902
Pathway

Apoptosis
Target

Adenosine Receptor
Recptor

Adenosine Receptor
Research Area

——
Indication

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CAS Number

136199-02-5
Formula Weight

356.46
Molecular Formula

C20H28N4O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 20 mg/mL (56.11 mM)
SMILES

O=C(N1CCC)N(CCC)C2=C(NC([C@@]3([C@@H]4C5)C[C@H](C4)C[C@H]5C3)=N2)C1=O
Chemical Name

8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

1. Mizumoto H, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):200-6. 2. Shimada J, et al. J Med Chem. 1992 Mar 6;35(5):924-30.

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