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Rolofylline
CAS No. 136199-02-5
Rolofylline( KW-3902 | KW3902 )
Catalog No. M11492 CAS No. 136199-02-5
A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
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| 5MG | 79 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 272 | In Stock |
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| 100MG | 403 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRolofylline
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
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DescriptionA potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM; displays 290-fold selectivity over A2AR; antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).Heart Failure Phase 3 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsKW-3902 | KW3902
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorAdenosine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number136199-02-5
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Formula Weight356.46
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Molecular FormulaC20H28N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (56.11 mM)
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SMILESO=C(N1CCC)N(CCC)C2=C(NC([C@@]3([C@@H]4C5)C[C@H](C4)C[C@H]5C3)=N2)C1=O
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Chemical Name8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Binodenoson
Binodenoson is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging.
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Solabegron
Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.
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Labetalol
Labetalol is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situations. The pharmacokinetics of labetalol is affected by the common CYP2C19 polymorphisms.
