Fidarestat( SNK-860 | SNK860 )

Catalog No. M11487 CAS No. 136087-85-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Fidarestat
Note

Research use only, not for human use.
Brief Description

Fidarestat (SNK860) is a potent aldose reductase inhibitor.
Description

Fidarestat (SNK860) is a potent aldose reductase inhibitor, improves motor nerve conduction velocity (MNCV) and metabolic abnormalities in sciatic nerve were investigated in acute STZ-induced diabetic rats.Diabetes Phase 3 Discontinued.
In Vitro

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In Vivo

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Synonyms

SNK-860 | SNK860
Pathway

Metabolic Enzyme/Protease
Target

Aldose Reductase
Recptor

Aldose Reductase
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

136087-85-9
Formula Weight

279.227
Molecular Formula

C12H10FN3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (895.35 mM)
SMILES

O=C([C@@H]1C[C@@](NC2=O)(C(N2)=O)C3=C(O1)C=CC(F)=C3)N
Chemical Name

(2S,4S)-6-fluoro-2',5'-dioxospiro[2,3-dihydrochromene-4,4'-imidazolidine]-2-carboxamide

1. Mizuno K, et al. 2. Hotta N, et al. Exp Physiol. 1995 Nov;80(6):981-9. 3. Kawamura T, et al. Diabet Med. 1995 May;12(5):392-6.

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