RO-2468( RO 2468 | RO2468 )

Catalog No. M11485 CAS No. 1360821-21-1

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Product Name

RO-2468
Note

Research use only, not for human use.
Brief Description

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.
Description

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.
In Vitro

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In Vivo

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Synonyms

RO 2468 | RO2468
Pathway

Apoptosis
Target

MDM2-p53
Recptor

MDM2-p53
Research Area

——
Indication

——

CAS Number

1360821-21-1
Formula Weight

614.499
Molecular Formula

C30H30Cl2FN5O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@H]1[C@H](C2=CC=CC(Cl)=C2F)[C@@]3(C4=C(NC3=O)C=C(Cl)N=C4)[C@H](CC(C)(C)C)N1)NC5=CC=C(C(N)=O)C=C5OC
Chemical Name

(2S,3R,4S,5R)-N-(4-carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide

1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.

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