Cart
sales@molnova.com
RO-2468
CAS No. 1360821-21-1
RO-2468( RO 2468 | RO2468 )
Catalog No. M11485 CAS No. 1360821-21-1
A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameRO-2468
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.
-
DescriptionA potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.
-
In Vitro——
-
In Vivo——
-
SynonymsRO 2468 | RO2468
-
PathwayApoptosis
-
TargetMDM2-p53
-
RecptorMDM2-p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1360821-21-1
-
Formula Weight614.499
-
Molecular FormulaC30H30Cl2FN5O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C([C@H]1[C@H](C2=CC=CC(Cl)=C2F)[C@@]3(C4=C(NC3=O)C=C(Cl)N=C4)[C@H](CC(C)(C)C)N1)NC5=CC=C(C(N)=O)C=C5OC
-
Chemical Name(2S,3R,4S,5R)-N-(4-carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.
molnova catalog
related products
-
STIMA 1
STIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro.
-
ML379
ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant).
-
APR-246
APR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity.
