Cart
sales@molnova.com
Naloxegol oxalate
CAS No. 1354744-91-4
Naloxegol oxalate( AZ 13337019 | NKTR-118 )
Catalog No. M11448 CAS No. 1354744-91-4
Naloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
|
| 5MG | 38 | In Stock |
|
| 10MG | 53 | In Stock |
|
| 25MG | 87 | In Stock |
|
| 50MG | 124 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNaloxegol oxalate
-
NoteResearch use only, not for human use.
-
Brief DescriptionNaloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
-
DescriptionNaloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. It was approved in 2014 in adult patients with chronic, non-Y pain. Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG.
-
In Vitro——
-
In Vivo——
-
SynonymsAZ 13337019 | NKTR-118
-
PathwayMetabolic Enzyme/Protease
-
TargetP450
-
RecptorCYP3A
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number1354744-91-4
-
Formula Weight741.828
-
Molecular FormulaC36H55NO15
-
Purity>98% (HPLC)
-
SolubilityDMSO：≥ 40 mg/mL
-
SMILESCOCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Naringin
Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
-
CYP1B1-IN-7
CYP1B1-IN-7 is a selective and potent CYP1B1 inhibitor showing cytotoxic effects in docetaxel-resistant CYP1B1 overexpressing MCF-7 cell lines, and can be used in synergistic treatment of cancer with anticancer compounds.
-
Azalanstat
Azalanstat (RS 21607) is an orally available selective mammalian lanosterol 14-alpha-demethylase inhibitor with hypocholesterolemic activity that inhibits cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes, and hamster livers through inhibition of the cytochrome P450 enzyme, lanosterol 14 alpha demethylase.
