Naloxegol oxalate( AZ 13337019 | NKTR-118 )

Catalog No. M11448 CAS No. 1354744-91-4

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Product Name

Naloxegol oxalate
Note

Research use only, not for human use.
Brief Description

Naloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
Description

Naloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. It was approved in 2014 in adult patients with chronic, non-Y pain. Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG.
In Vitro

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In Vivo

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Synonyms

AZ 13337019 | NKTR-118
Pathway

Metabolic Enzyme/Protease
Target

P450
Recptor

CYP3A
Research Area

Neurological Disease
Indication

——

CAS Number

1354744-91-4
Formula Weight

741.828
Molecular Formula

C36H55NO15
Purity

>98% (HPLC)
Solubility

DMSO：≥ 40 mg/mL
SMILES

COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O
Chemical Name

——

1.Bui K, et al. J Clin Pharmacol. 2016 Aug;56(8):1019-27.

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