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Elacestrant dihydrochloride
CAS No. 1349723-93-8
Elacestrant dihydrochloride( RAD-1901 dihydrochloride )
Catalog No. M11413 CAS No. 1349723-93-8
Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 278 | In Stock |
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| 5MG | 237 | In Stock |
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| 10MG | 376 | In Stock |
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| 25MG | 632 | In Stock |
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| 50MG | 881 | In Stock |
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| 100MG | 1190 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameElacestrant dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionElacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).
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DescriptionElacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD); inhibits ERα expression in MCF-7 cells (IC50=0.6 nM); induces the degradation of ER, inhibits ER-mediated signaling and growth of ER+ breast cancer cell lines in vitro and in vivo, and significantly inhibits tumor growth of multiple PDX models.Breast Cancer Phase 2 Clinical.
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In VitroCell Proliferation Assay Cell Line:ER-positive MCF-7 cells (Estradiol (E2)-stimulated)Concentration:0-1 μM Incubation Time:48 h Result:Showed antiproliferative activity on cells.Western Blot Analysis Cell Line:MCF-7 cells Concentration:0.5 nM-10 μM Incubation Time:48 h Result:Inhibited ERα expression (EC50 of 0.6 nM) in a dose-dependent manner.Western Blot AnalysisCell Line:MCF7, T47D, and HCC1428 cells Concentration:0-1 μM Incubation Time:24 or 48 h Result:Decreased the expression of estrogen receptor protein.
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In Vivo——
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SynonymsRAD-1901 dihydrochloride
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen Receptor/ERR
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number1349723-93-8
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Formula Weight531.5568
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Molecular FormulaC30H40Cl2N2O2
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Purity>98% (HPLC)
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SolubilityDMSO: 17.6 mg/mL
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SMILES——
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Chemical Name2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, hydrochloride (1:2), (6R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wardell SE, et al. Endocr Relat Cancer. 2015 Oct;22(5):713-24.
2. Garner F, et al. Anticancer Drugs. 2015 Oct;26(9):948-56.
3. Bihani T, et al. Clin Cancer Res. 2017 May 4. pii: clincanres.2561.2016.
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