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GSK343
CAS No. 1346704-33-3
GSK343( GSK343 | GSK-343 | GSK 343 )
Catalog No. M11407 CAS No. 1346704-33-3
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
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| 5MG | 51 | In Stock |
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| 10MG | 83 | In Stock |
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| 25MG | 172 | In Stock |
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| 50MG | 276 | In Stock |
|
| 100MG | 500 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK343
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NoteResearch use only, not for human use.
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Brief DescriptionGSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1.
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DescriptionGSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases.
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In Vitro——
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In Vivo——
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SynonymsGSK343 | GSK-343 | GSK 343
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorEZH1| EZH2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1346704-33-3
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Formula Weight541.69
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Molecular FormulaC31H39N7O2
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Purity>98% (HPLC)
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SolubilityEthanol: 4 mg/mL (7.38 mM); DMSO: 1 mg/mL warmed (1.84 mM)
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SMILESO=C(C1=CC(C2=CC(N3CCN(C)CC3)=NC=C2)=CC4=C1C=NN4C(C)C)NCC5=C(CCC)C=C(C)NC5=O
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Chemical Name1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide.
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Verma SK, et al. ACS Med Chem Lett. 2012, 3, 1091-1096.
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