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Avacopan
CAS No. 1346623-17-3
Avacopan( CCX-168 | CCX168 )
Catalog No. M11405 CAS No. 1346623-17-3
Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 120 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 264 | In Stock |
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| 50MG | 415 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAvacopan
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NoteResearch use only, not for human use.
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Brief DescriptionAvacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.
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DescriptionAvacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM; shows no activity (IC50 >5,000 nM)for C5aR-related receptors C5L2, C3aR, ChemR23, GPR1 and FPR1; inhibits C5a-mediated chemotaxis of U937 cells with pA2 of 0.2 nM; shows activity in mouse model of ANCA-induced glomerulonephritis.Other Indication Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsCCX-168 | CCX168
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PathwayImmunology/Inflammation
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TargetComplement System
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RecptorComplement System
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1346623-17-3
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Formula Weight581.656
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Molecular FormulaC33H35F4N3O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 10.1 mg/mL 17.36 mM; H2O : < 0.1 mg/mL
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SMILESO=C([C@@H]1[C@H](C2=CC=C(NC3CCCC3)C=C2)N(C(C4=C(C)C=CC=C4F)=O)CCC1)NC5=CC=C(C)C(C(F)(F)F)=C5
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Chemical Name(2R,3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xiao H, et al. J Am Soc Nephrol. 2014 Feb;25(2):225-31.
2. Bekker P, et al. PLoS One. 2016 Oct 21;11(10):e0164646.
3. Jayne DRW, et al. J Am Soc Nephrol. 2017 Sep;28(9):2756-2767.
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