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GF109203X
CAS No. 133052-90-1
GF109203X( BIM I | GF 109203X | G? 6850 )
Catalog No. M11312 CAS No. 133052-90-1
GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 96 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 343 | In Stock |
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| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGF109203X
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NoteResearch use only, not for human use.
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Brief DescriptionGF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively.
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DescriptionGF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
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In Vitro——
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In VivoAnimal Model: Quinpirole-treated shrews Dosage:0-20 mg/kg Administration:i.p.Result:Reduced the mean frequency of Quinpirole-induced vomiting.Blocked Quinpirole-mediated ERK1/2 phosphorylation in shrew brainstems.
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SynonymsBIM I | GF 109203X | G? 6850
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PathwayAngiogenesis
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TargetPDGFR
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RecptorPDGFR| PKCα| PKCβ1| PKCβ2| PKCγ
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number133052-90-1
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Formula Weight412.48
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Molecular FormulaC25H24N4O2
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Purity>98% (HPLC)
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SolubilityDMSO:82 mg/mL (198.79 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
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SMILESO=C(C(C1=CN(CCCN(C)C)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O.
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Chemical Name3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Toullec D, et al. J Biol Chem. 1991, 266(24), 15771-15781.
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