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Hydrazinocurcumin
CAS No. 131068-23-0
Hydrazinocurcumin( —— )
Catalog No. M11244 CAS No. 131068-23-0
Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameHydrazinocurcumin
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NoteResearch use only, not for human use.
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Brief DescriptionHydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity.
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DescriptionHydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets; suppresses cell proliferation, depresses cell migration and invasion, induces cell apoptosis; inhibits the cell cycle progression of colon cancer cells via antagonizing of Ca2+/calmodulin functions.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number131068-23-0
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Formula Weight364.401
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Molecular FormulaC21H20N2O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4,4'-((1E,1'E)-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shim JS, et al. Bioorg Med Chem. 2002 Sep;10(9):2987-92.
2. Shim JS, et al. Bioorg Med Chem. 2002 Aug;10(8):2439-44.
3. Wang X, et al. Int J Oncol. 2012 Apr;40(4):1189-95.
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