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Hydrazinocurcumin

CAS No. 131068-23-0

Hydrazinocurcumin( —— )

Catalog No. M11244 CAS No. 131068-23-0

Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hydrazinocurcumin
  • Note
    Research use only, not for human use.
  • Brief Description
    Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity.
  • Description
    Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets; suppresses cell proliferation, depresses cell migration and invasion, induces cell apoptosis; inhibits the cell cycle progression of colon cancer cells via antagonizing of Ca2+/calmodulin functions.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    131068-23-0
  • Formula Weight
    364.401
  • Molecular Formula
    C21H20N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4,4'-((1E,1'E)-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shim JS, et al. Bioorg Med Chem. 2002 Sep;10(9):2987-92. 2. Shim JS, et al. Bioorg Med Chem. 2002 Aug;10(8):2439-44. 3. Wang X, et al. Int J Oncol. 2012 Apr;40(4):1189-95.
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