Ravidasvir dihydrochloride( PPI-668 | BI 238630 )

Catalog No. M11217 CAS No. 1303533-81-4

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HNMR

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Product Name

Ravidasvir dihydrochloride
Note

Research use only, not for human use.
Brief Description

Ravidasvir (PPI-668;BI 238630) is a potent pan-genotypic HCV NS5A inhibitor with IC50 of 0.12/0.01/1.14 nM for HCV gt-1a/1b/3a in replicon luciferase assay.
Description

Ravidasvir (PPI-668;BI 238630) is a potent pan-genotypic HCV NS5A inhibitor with IC50 of 0.12/0.01/1.14 nM for HCV gt-1a/1b/3a in replicon luciferase assay; has been well tolerated and shown high sustained viral response rates as a key component in all-oral combination regimens in multiple human clinical trials.HCV Infection Phase 3 Clinical.
In Vitro

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In Vivo

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Synonyms

PPI-668 | BI 238630
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

Infection
Indication

HCV Infection

CAS Number

1303533-81-4
Formula Weight

835.828
Molecular Formula

C42H52Cl2N8O6
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C)C(C(=O)N1CCCC1C2=NC3=C(N2)C=C(C=C3)C4=CC5=C(C=C4)C=C(C=C5)C6=CN=C(N6)C7CCCN7C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC.Cl.Cl
Chemical Name

Methyl N-[(2S)-1-{(2S)-2-[5-(6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}naphthalen-2-yl)-1H-benzimidazol-2-yl]pyrrolidin-1-yl}-3-methyl-1-oxobutan-2-yl]carbamate dihydrochloride

1. Zhong M, et al. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4508-12.

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