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Velpatasvir
CAS No. 1377049-84-7
Velpatasvir( GS-5816 | GS 5816 | GS5816 )
Catalog No. M11558 CAS No. 1377049-84-7
Velpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 42 | In Stock |
|
| 50MG | 95 | In Stock |
|
| 100MG | 147 | In Stock |
|
| 200MG | 219 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameVelpatasvir
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NoteResearch use only, not for human use.
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Brief DescriptionVelpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.
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DescriptionVelpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.HCV Infection Phase 3 Clinical.
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In Vitro——
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In VivoAnimal Model:CCl4-induced non-HCV rat model Dosage:10 mg/kg/d alone, or in combination with Sofosbuvir (20 mg/kg/d) Administration:p.o.Result:Decreased the levels of TNF-a, NF-κB and IL-6 in serum and hepatic tissues.Inhibited hepatic stellate cells (HSCs).
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SynonymsGS-5816 | GS 5816 | GS5816
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCVNS5A
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number1377049-84-7
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Formula Weight883.0018
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Molecular FormulaC49H54N8O8
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Purity>98% (HPLC)
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SolubilityDMSO: 146.66 mg/mL (Need ultrasonic and warming)
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SMILESO=C(OC)N[C@H](C1=CC=CC=C1)C(N2[C@H](C3=NC=C(C4=CC5=C(C6=CC7=CC=C8C(NC([C@H]9N(C([C@H](C(C)C)NC(OC)=O)=O)[C@@H](C)CC9)=N8)=C7C=C6OC5)C=C4)N3)C[C@H](COC)C2)=O
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Chemical NameCarbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Curry MP, et al. N Engl J Med. 2015 Dec 31;373(27):2618-28.
2. Gane EJ, et al. Gastroenterology. 2016 Sep;151(3):448-456.e1.
3. Nakamoto S, et al. World J Gastroenterol. 2014 Mar 21;20(11):2902-12.
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