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Velpatasvir

CAS No. 1377049-84-7

Velpatasvir( GS-5816 | GS 5816 | GS5816 )

Catalog No. M11558 CAS No. 1377049-84-7

Velpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 49 In Stock
5MG 29 In Stock
10MG 45 In Stock
25MG 72 In Stock
50MG 98 In Stock
100MG 152 In Stock
200MG 226 In Stock
500MG 369 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Velpatasvir
  • Note
    Research use only, not for human use.
  • Brief Description
    Velpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.
  • Description
    Velpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.HCV Infection Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:CCl4-induced non-HCV rat model Dosage:10 mg/kg/d alone, or in combination with Sofosbuvir (20 mg/kg/d) Administration:p.o.Result:Decreased the levels of TNF-a, NF-κB and IL-6 in serum and hepatic tissues.Inhibited hepatic stellate cells (HSCs).
  • Synonyms
    GS-5816 | GS 5816 | GS5816
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCVNS5A
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    1377049-84-7
  • Formula Weight
    883.0018
  • Molecular Formula
    C49H54N8O8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 146.66 mg/mL (Need ultrasonic and warming)
  • SMILES
    O=C(OC)N[C@H](C1=CC=CC=C1)C(N2[C@H](C3=NC=C(C4=CC5=C(C6=CC7=CC=C8C(NC([C@H]9N(C([C@H](C(C)C)NC(OC)=O)=O)[C@@H](C)CC9)=N8)=C7C=C6OC5)C=C4)N3)C[C@H](COC)C2)=O
  • Chemical Name
    Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Curry MP, et al. N Engl J Med. 2015 Dec 31;373(27):2618-28. 2. Gane EJ, et al. Gastroenterology. 2016 Sep;151(3):448-456.e1. 3. Nakamoto S, et al. World J Gastroenterol. 2014 Mar 21;20(11):2902-12.
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