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Y-27632 dihydrochloride
CAS No. 129830-38-2
Y-27632 dihydrochloride( —— )
Catalog No. M11202 CAS No. 129830-38-2
Y-27632 2hydrochloride is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 33 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 42 | In Stock |
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| 25MG | 78 | In Stock |
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| 50MG | 130 | In Stock |
|
| 100MG | 217 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameY-27632 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionY-27632 2hydrochloride is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay.
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DescriptionY-27632 2hydrochloride is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.(In Vitro):Y-27632 (1-5 μM; 0-60 min) promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs) .Y-27632 (1-5 μM; 0-60 min) induces the expression of NSE, MAP-2 and nestin in ADSCs .(In Vivo):Y-27632 (oral gavage; 30 mg/kg; once daily; 4 w) prevents dimethylnitrosamine-induced hepatic fibrosis in rats.Y-27632 (oral gavage; 5-10 mg/kg; once) shows antiepileptic effects in epilepsy induced by PTZ and MES.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK1 (p160ROCK)| ROCK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number129830-38-2
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Formula Weight320.26
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Molecular FormulaC14H21N3O·2HCl
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Purity>98% (HPLC)
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SolubilityWater: 14 mg/mL (43.71 mM); DMSO: 64 mg/mL warmed (199.83 mM)
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SMILESC[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Uehata M, et al. Nature, 1997, 389(6654), 990-994.
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