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TBK1-IN-1
CAS No. 1292310-49-6
TBK1-IN-1( MDK10496 | MDK10496 | MDK10496 | IKKε-IN-1 )
Catalog No. M11183 CAS No. 1292310-49-6
TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 188 | In Stock |
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| 5MG | 188 | In Stock |
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| 10MG | 306 | In Stock |
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| 25MG | 487 | In Stock |
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| 50MG | 646 | In Stock |
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| 100MG | 830 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTBK1-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionTBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor.
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DescriptionTBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM; inhibits IRF3 nuclear translocation with IC50 of 95 nM, but does not significantly inhibits cell proliferation in some NSCLC, pancreatic, and colorectal cell lines.
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In VitroTBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM.
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In Vivo——
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SynonymsMDK10496 | MDK10496 | MDK10496 | IKKε-IN-1
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIκB kinase (IKK)
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1292310-49-6
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Formula Weight457.5243
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Molecular FormulaC26H27N5O3
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Purity>98% (HPLC)
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SolubilityDMSO: 21.5 mg/mL
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SMILESN#CC1=CC(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)=CC=C1OC5CCOCC5
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Chemical NameBenzonitrile, 5-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Muvaffak A, et al. Mol Cancer Res. 2014 Jul;12(7):1055-66.
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