Balofloxacin

Research use only, not for human use.

Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.

Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.(In Vitro):Balofloxacin (25 mg/mL; 1 h) decreases the growth of S. aureus that adhered to human corneal epithelial cells (HCECs).Balofloxacin inhibits the S. aureus ATCC 25923, with a MIC of 0.125 mg/mL.Balofloxacin (0.05-500 μg/mL; 72 h) does not induce toxicity on the HCECs at a low concentration, such as 0.625 mg/mL.(In Vivo):Balofloxacin (200 mg/kg/day; p.o. for 5 d) reduces the counts of viable M. pneumonia in the lungs of hamsters.Balofloxacin eye drops (0.5%) is effective in S. aureus bacterial keratitis of rabbits.

Balofloxacin (25 mg/mL; 1 h) decreases the growth of S. aureus that adhered to human corneal epithelial cells (HCECs).Balofloxacin inhibits the S. aureus ATCC 25923, with a MIC of 0.125 mg/mL.Balofloxacin (0.05-500 μg/mL; 72 h) does not induce toxicity on the HCECs at a low concentration, such as 0.625 mg/mL.

Balofloxacin (200 mg/kg/day; p.o. for 5 d) reduces the counts of viable M. pneumonia in the lungs of hamsters.Balofloxacin eye drops (0.5%) is effective in S. aureus bacterial keratitis of rabbits.

Q-35

Cell Cycle/DNA Damage

DNA gyrase

DNA gyrase

Infection

——

127294-70-6

389.42

C20H24FN3O4

>98% (HPLC)

DMSO: 5 mg/mL (12.83 mM)

CNC1CCCN(C1)c2c(cc3c(c2OC)n(cc(c3=O)C(=O)O)C4CC4)F

(+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-(methylamino)piperidino)-4-oxo-3-quinolinecarboxylic acid

(-20℃)

With Ice Pack

≥ 2 years