SOMG-833( SOMG 833 | SOMG833 )

Catalog No. M11122 CAS No. 1268264-10-3

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Product Name

SOMG-833
Note

Research use only, not for human use.
Brief Description

A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM.
Description

A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo.
In Vitro

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In Vivo

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Synonyms

SOMG 833 | SOMG833
Pathway

Angiogenesis
Target

c-Met/HGFR
Recptor

c-Met/HGFR
Research Area

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Indication

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CAS Number

1268264-10-3
Formula Weight

445.446
Molecular Formula

C22H22F3N5O2
Purity

>98% (HPLC)
Solubility

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SMILES

CN1CCN(CC1)C2=CC3=C(C=C(C=C3NCC4=CC(=CC=C4)[N+](=O)[O-])C(F)(F)F)N=C2
Chemical Name

3-(4-methylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7-(trifluoromethyl) quinoline

1. Zhang HT, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):36-45.

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