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JTZ-951 hydrochloride
CAS No. 1262131-60-1
JTZ-951 hydrochloride( JTZ 951 | JTZ951 | Enarodustat )
Catalog No. M11089 CAS No. 1262131-60-1
A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1323 | Get Quote |
|
| 50MG | 2682 | Get Quote |
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| 100MG | 3600 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameJTZ-951 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
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DescriptionA novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2; increases EPO release from Hep3B cells with EC50 of 5.7 uM, increases hemoglobin levels in rats.Anemia Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsJTZ 951 | JTZ951 | Enarodustat
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF/HIF Prolyl-hydroxylase
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Research AreaOther Indications
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IndicationAnemia
Chemical Information
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CAS Number1262131-60-1
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Formula Weight376.797
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Molecular FormulaC17H17ClN4O4
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC=C(C=C1)CCC2=CC(=O)C(=C3N2NC=N3)C(=O)NCC(=O)O.Cl
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Chemical Name(7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yosuke Ogoshi, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1320-1325.
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