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Tenovin-D3
CAS No. 1258283-70-3
Tenovin-D3( Tenovin D3 )
Catalog No. M11063 CAS No. 1258283-70-3
A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTenovin-D3
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NoteResearch use only, not for human use.
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Brief DescriptionA novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM.
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DescriptionA novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM; shows much weaker actvity for SIRT1 (IC50>90 uM), SIRT3 and HDAC8; promotes expression of the cell-cycle regulator and p53 target p21(WAF1/CIP1) (CDKN1A) in a p53-independent manner, fails to increase p53 levels or transcription factor activity.
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In Vitro——
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In Vivo——
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SynonymsTenovin D3
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSirtuin
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Research Area——
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Indication——
Chemical Information
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CAS Number1258283-70-3
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Formula Weight533.893
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Molecular FormulaC22H27Cl3N4O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC(Cl)=C(OC)C(Cl)=C2.[H]Cl
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Chemical Name3,5-dichloro-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)-4-methoxybenzamide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McCarthy AR, et al. Mol Cancer Ther. 2013 Apr;12(4):352-60.
2. Liu R, et al. Sci Rep. 2015 Feb 12;5:8415.
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