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CDK4-IN-1

CAS No. 1256963-02-6

CDK4-IN-1( LEE011 analog | CDK4-IN-1 | CDK4IN-1 | CDK4-IN1 )

Catalog No. M11055 CAS No. 1256963-02-6

CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CDK4-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM.
  • Description
    CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    LEE011 analog | CDK4-IN-1 | CDK4IN-1 | CDK4-IN1
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK4| Cyclin D1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1256963-02-6
  • Formula Weight
    440.97
  • Molecular Formula
    C22H29ClN8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    CN(C1CCN(C2=CN=C(NC3=NC=CC(C4=C(C(C)C)NN=C4Cl)=N3)C=C2)CC1)C
  • Chemical Name
    4-(3-Chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]pyrimidin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cho YS, et al. J Med Chem. 2010 Nov 25;53(22):7938-57.
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