CDK4-IN-1( LEE011 analog | CDK4-IN-1 | CDK4IN-1 | CDK4-IN1 )

Catalog No. M11055 CAS No. 1256963-02-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CDK4-IN-1
Note

Research use only, not for human use.
Brief Description

CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM.
Description

CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively.
In Vitro

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In Vivo

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Synonyms

LEE011 analog | CDK4-IN-1 | CDK4IN-1 | CDK4-IN1
Pathway

Angiogenesis
Target

CDK
Recptor

CDK4| Cyclin D1
Research Area

——
Indication

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CAS Number

1256963-02-6
Formula Weight

440.97
Molecular Formula

C22H29ClN8
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

CN(C1CCN(C2=CN=C(NC3=NC=CC(C4=C(C(C)C)NN=C4Cl)=N3)C=C2)CC1)C
Chemical Name

4-(3-Chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]pyrimidin-2-amine

1.Cho YS, et al. J Med Chem. 2010 Nov 25;53(22):7938-57.

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