MPT0B098

Research use only, not for human use.

A potent microtubule inhibitor that not only inhibits the expression levels of HIF-1α protein but also destabilizes HIF-1α mRNA.

A potent microtubule inhibitor that not only inhibits the expression levels of HIF-1α protein but also destabilizes HIF-1α mRNA; binds to the colchicine-binding site of tubulin, inhibits growth of various human cancer cells, including chemoresistant cells with IC50 70-150 nM; exhibit less inhibitory effect against human umbilical vein endothelial cells (HUVEC) with IC50 of 510 nM, arrests cells in the G2-M phase and induces cell apoptosis; effectively suppresses tumor growth and microvessel density of tumor specimens in vivo.

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MPT0B 098 | MPT0B-098

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

Microtubule/Tubulin

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1254363-89-7

366.43

C20H18N2O3S

>98% (HPLC)

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O=S(N1CCC2=C1C(C3=CC=NC=C3)=CC=C2)(C4=CC=C(OC)C=C4)=O

1-((4-methoxyphenyl)sulfonyl)-7-(pyridin-4-yl)indoline

(-20℃)

With Ice Pack

≥ 2 years