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BI-69A11
CAS No. 1233322-09-2
BI-69A11( BI-69A11 | BI 69A11 | BI69A11 )
Catalog No. M10923 CAS No. 1233322-09-2
A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 53 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 43 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 107 | In Stock |
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| 50MG | 152 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBI-69A11
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.
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DescriptionA potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1; displays no activity for other protein kinases including Abl1, p38α, JNK, and PI3K (IC50>100 uM); causes partial inhibition of AKT phosphorylation on S473 on melanoma cells at 3 uM; reduces AKT protein expression and AKT association with HSP-90; caused effective regression of melanoma tumor xenografts.
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In Vitro——
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In Vivo——
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SynonymsBI-69A11 | BI 69A11 | BI69A11
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research Area——
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Indication——
Chemical Information
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CAS Number1233322-09-2
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Formula Weight425.872
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Molecular FormulaC25H16ClN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC2=C(C=C(Cl)C=C2)C(C3=CC=CC=C3)=C1C(/C=C/C4=NC5=CC=CC=C5N4)=O
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Chemical Name(E)-3-(3-(1H-benzo[d]imidazol-2-yl)acryloyl)-6-chloro-4-phenylquinolin-2(1H)-one(E)-3-(3-(1H-benzo[d]imidazol-2-yl)acryloyl)-6-chloro-4-phenylquinolin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gaitonde S, et al. Pigment Cell Melanoma Res. 2009 Apr;22(2):187-95.
2. Feng Y, et al. Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42.
3. Pal I, et al. Br J Cancer. 2014 Jul 8;111(1):101-11.
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