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Candoxatrilat

CAS No. 123122-54-3

Candoxatrilat( UK 73967 )

Catalog No. M10911 CAS No. 123122-54-3

A potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Candoxatrilat
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor.
  • Description
    A potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor that increases endogenous ANF levels and produces natriuretic and diuretic responses intravenously in mice.Heart Failure Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    UK 73967
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Neprilysin
  • Recptor
    Neprilysin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    123122-54-3
  • Formula Weight
    399.484
  • Molecular Formula
    C20H33NO7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COCCOC[C@@H](C(=O)O)CC1(CCCC1)C(=O)N[C@H]2CC[C@H](CC2)C(=O)O
  • Chemical Name
    4-[[1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Danilewicz JC, et al. Biochem Biophys Res Commun. 1989 Oct 16;164(1):58-65. 2. Shepperson NB, et al. Br J Pharmacol. 1989 Dec;98 Suppl:822P. 3. Jardine AG, et al. Am J Hypertens. 1990 Sep;3(9):661-7. 4. Northridge DB, et al. Lancet. 1989 Sep 9;2(8663):591-3.
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