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VMY-1-103

CAS No. 1209002-43-6

VMY-1-103( VMY 1-103 )

Catalog No. M10779 CAS No. 1209002-43-6

A novel dansylated analog of purvalanol B, and a CDK inhibitor that inhibits cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    VMY-1-103
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel dansylated analog of purvalanol B, and a CDK inhibitor that inhibits cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B.
  • Description
    A novel dansylated analog of purvalanol B, and a CDK inhibitor that inhibits cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B; increases the sub G(1) fraction of apoptotic cells, induces PARP and caspase-3 cleavage and increases the levels of the death receptors DR4 and DR5, Bax and Bad.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    VMY 1-103
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1209002-43-6
  • Formula Weight
    708.27
  • Molecular Formula
    C34H42ClN9O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NCCNS(=O)(C1=C2C=CC=C(N(C)C)C2=CC=C1)=O)C3=CC=C(NC4=C5N=CN(C(C)C)C5=NC(N[C@H](C(C)C)CO)=N4)C=C3Cl
  • Chemical Name
    2-Chloro-N-[2-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]ethyl]-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ringer L, et al. Cancer Biol Ther. 2011 Nov 1;12(9):818-26. 2. Sirajuddin P, et al. Cell Cycle. 2012 Oct 15;11(20):3801-9. 3. Waye S, et al. Aging (Albany NY). 2015 Oct;7(10):854-68.
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