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PF 04942847
CAS No. 1207961-33-8
PF 04942847( PF-04942847 | PF04942847 )
Catalog No. M10770 CAS No. 1207961-33-8
An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF 04942847
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NoteResearch use only, not for human use.
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Brief DescriptionAn orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM.
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DescriptionAn orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM; maintains potency toward HSP90 client protein degradation in various cellular assay with AKT IC50 of 20-100 nM, demonstrates tumor growth inhibition in the MDA-MB-231 xenograft model.
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In Vitro——
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In Vivo——
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SynonymsPF-04942847 | PF04942847
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research Area——
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Indication——
Chemical Information
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CAS Number1207961-33-8
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Formula Weight509.918
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Molecular FormulaC22H23ClF3N7O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC(=CC(=C1C2=NC(=NC3=C2CN(C3)C(=O)NCC(C)(F)F)N)OCCN4C=C(C=N4)F)Cl
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Chemical Name2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yamazaki S, et al. J Pharmacol Exp Ther. 2011 Sep;338(3):964-73.
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