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AZD 8683
CAS No. 1194737-07-9
AZD 8683( AZD-8683 | AZD8683 )
Catalog No. M10685 CAS No. 1194737-07-9
A highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAZD 8683
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.
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DescriptionA highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4; reverse airflow obstruction by antagonizing para-sympathetic bronchoconstricting effects within the airways, shows potential for chronic obstructive pulmonary disease (COPD) management. COPD Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAZD-8683 | AZD8683
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PathwayGPCR/G Protein
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TargetmAChR
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RecptormAChR
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number1194737-07-9
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Formula Weight542.518
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Molecular FormulaC28H36BrN3O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(R)-1-(2-oxo-2-(pyridin-2-ylamino)ethyl)-3-((1-phenylcycloheptane-1-carbonyl)oxy)quinuclidin-1-ium bromide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53.
2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174.
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