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Sinogliatin

CAS No. 1191996-10-7

Sinogliatin( Dorzagliatin | HMS-5552 | RO-5305552 )

Catalog No. M10662 CAS No. 1191996-10-7

Sinogliatin (Dorzagliatin, HMS-5552, RO-5305552) is a novel, first-in-class glucokinase activator (GKS) to treat diabetes mellitus.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sinogliatin
  • Note
    Research use only, not for human use.
  • Brief Description
    Sinogliatin (Dorzagliatin, HMS-5552, RO-5305552) is a novel, first-in-class glucokinase activator (GKS) to treat diabetes mellitus.
  • Description
    Sinogliatin (Dorzagliatin, HMS-5552, RO-5305552) is a novel, first-in-class glucokinase activator (GKS) to treat diabetes mellitus.Diabetes Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Dorzagliatin | HMS-5552 | RO-5305552
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    Glucokinase
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    1191996-10-7
  • Formula Weight
    462.93
  • Molecular Formula
    C22H27ClN4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)C[C@H](N1CC(OC2=CC=CC=C2Cl)=CC1=O)C(NC3=NN(C[C@H](O)CO)C=C3)=O
  • Chemical Name
    (S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Song L, et al. Clin Pharmacokinet. 2018 Oct;57(10):1307-1323.
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